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Plasma Guns. When it comes down to their use, you'll have to count me along the fan base. Losing a couple guardsmen really isn't that much of a deal to me, if the enemy is close enough for me to use them. I will probably be losing those guardsmen anyways, so they need to kill something reliably. I often use them in veteran guardsmen units, so 3 plasma guns is getting me rapid fire shots. How can you not love the damage that is about to rip into the enemy. In a tight spot, they can even destroy a vehicle. Now a marine with a 3+ save, is even less likely to die due to melt down, so its not so much of a big deal to them. As for their damage, models die in waves to my plasma guns on the table, since I tend to field more than one unit of them.
Imperial Guard. Groups of 3 are quite easy to get in veterans. Stick them into a chimera, and they are quick and flexible on the battlefield. Into company command squads, 3 or 4 of them can be used. A medic will give them feel no pain, however, I'm still going to use 4 in the squad personally. Nothing like 8 str7 ap2 shots at BS4 to slow down the enemy. Can you say dead monstrous creature. Don't forget to take leadership tests though if you lose 25% of your own unit. I tend to field 2 veteran units in chimeras with plasma guns, and 2 with melta guns. Other plasma guns are found in command squads, and guardsmen retinues with inquisitors. My Faeit 212 army list fields 11 or 12 plasma guns to punish an enemy that gets in close to my chimeras.
Blood Angels. First thing I saw, Honor Guard can take 4 plasma guns. They radiate their feel no pain and furious charge up to 6" so I didn't want to send them into the fray, but instead weaken up the enemy as my fast moving assault troops moved past them into the assault. Just throw them into a transport to have them keep up.
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