With the rules out for the Adeptus Custodes and Sisters of Silence for Warhammer 40,000, there is a big gap since there is no rules on how to field them. This leaves them for Unbound games only following the rules. However... friendly games I am certain will them fielded, at least until both forces are expanded upon and get a codex release.
Response on Facebook
"The kits in this set are designed primarily for Horus Heresy games, but rules are provided to let you add them to your Warhammer 40,000 games if you want to. You are quite right – currently this is limited to Unbound games, or you and your opponent agreeing they can be included for some other narrative reason.
Neither force is currently an active military force in the galaxy (The Adeptus Custodes don't leave Terra, and the Sister of Silence have not bean widely active for 9,000 years) , so they don't feature in any current Imperial formations, which tend to reflect active forces at the close of the 41st millennium.
Both do still exist though, so who knows, we might just see more of them in future."